BRUNNER, H and SPERL, G (1993) SYNTHESIS AND ANTITUMOR-ACTIVITY OF PT(II) COMPLEXES OF ESTRADIOL DERIVATIVES. MONATSHEFTE FUR CHEMIE, 124 (1). pp. 83-102. ISSN 0026-9247,
Full text not available from this repository.Abstract
Estrogen-receptor binding moieties were introduced into Pt(II) complexes in order to facilitate the selective transport into cancer cells. Estradiol esters of 2,3-diaminopropionic acid and estradiol ethers of 1,2-diamino-2-methyl-3-(p-hydroxyphenyl)propane were attached to Pt(II) complexes. The antitumor activity of the compounds was tested towards the human mammary carcinoma cell lines MDA-MB 231 and MCF-7, respectively, and the estrogen-receptor binding affinity of the Pt(II) complexes was determined. The steroidal Pt(II) complexes gave a maximum growth inhibition of 80% and a maximum estrogen-receptor binding affinity of 5.18.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BIOLOGICALLY IMPORTANT LIGANDS; DEPENDENT MAMMARY-CARCINOMA; ESTROGEN-RECEPTOR; METAL-COMPLEXES; ENANTIOSELECTIVE HYDROSILYLATION; PLATINUM COMPLEXES; STEROIDAL HORMONES; CELL-LINES; ANALOGS; BINDING; ESTRADIOL DERIVATIVES; PLATINUM(II) COMPLEXES; HUMAN MAMMARY CARCINOMA CELL LINES MDA-MB 231 AND MCF-7; ANTITUMOR ACTIVITY; ESTROGEN-RECEPTOR BINDING |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54206 |
Actions (login required)
 |
View Item |
