Heussinger, Nicole and Kontopantelis, Evangelos and Gburek-Augustat, Janina and Jenke, Andreas and Vollrath, Gesa and Korinthenberg, Rudolf and Hofstetter, Peter and Meyer, Sascha and Brecht, Isabel and Kornek, Barbara and Herkenrath, Peter and Schimmel, Mareike and Wenner, Kirsten and Haeusler, Martin and Lutz, Soeren and Karenfort, Michael and Blaschek, Astrid and Smitka, Martin and Karch, Stephanie and Piepkorn, Martin and Rostasy, Kevin and Luecke, Thomas and Weber, Peter and Trollmann, Regina and Klepper, Joerg and Haeussler, Martin and Hofmann, Regina and Weissert, Robert and Merkenschlager, Andreas and Buttmann, Mathias (2015) Oligoclonal bands predict multiple sclerosis in children with optic neuritis. ANNALS OF NEUROLOGY, 77 (6). pp. 1076-1082. ISSN 0364-5134, 1531-8249
Full text not available from this repository. (Request a copy)Abstract
We retrospectively evaluated predictors of conversion to multiple sclerosis (MS) in 357 children with isolated optic neuritis (ON) as a first demyelinating event who had a median follow-up of 4.0 years. Multiple Cox proportional-hazards regressions revealed abnormal cranial magnet resonance imaging (cMRI; hazard ratio [HR]=5.94, 95% confidence interval [CI]=3.39-10.39, p<0.001), presence of cerebrospinal fluid immunoglobulin G oligoclonal bands (OCB; HR=3.69, 95% CI=2.32-5.86, p<0.001), and age (HR=1.08 per year of age, 95% CI=1.02-1.13, p=0.003) as independent predictors of conversion, whereas sex and laterality (unilateral vs bilateral) had no influence. Combined cMRI and OCB positivity indicated a 26.84-fold higher HR for developing MS compared to double negativity (95% CI=12.26-58.74, p<0.001). Accordingly, cerebrospinal fluid analysis may supplement cMRI to determine the risk of MS in children with isolated ON. Ann Neurol 2015;77:1076-1082
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHILDHOOD; CRITERIA; RISK; MRI; CNS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2019 08:45 |
| Last Modified: | 15 Jul 2019 08:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5432 |
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