ALBAN, S and KRAUS, J and FRANZ, G (1992) SYNTHESIS OF LAMINARIN SULFATES WITH ANTICOAGULANT ACTIVITY. ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 42-2 (8). pp. 1005-1008. ISSN 0004-4172,
Full text not available from this repository.Abstract
Laminarin sulfates were synthesized without significant degradation of the genuine laminarin chain using SO3/pyridine complex as a sulfation reagent. 6 derivatives with a degree of sulfation (d. s.) ranging from 0.30 to 2.26 could be obtained. According to methylation analysis the C-6-OH-groups of the glucose molecules were preferentially substituted, followed by the OH-groups at C-2 and C-4. The derivatives Lam S1 (d. s. = 0.30) and Lam S2 (d. s. = 0.64) showed no activity in the blood coagulation tests. With increasing d s. the anticoagulant activity increased until an optimum d s. of 1.49. Anticoagulant laminarin sulfates showed significant activity in the activated partial thromboplastin time (APTT) test but were less active in the anti-Factor Xa as well as anti-Factor IIa assay. Therefore, the anticoagulant activity of the synthesized laminarin sulfates is due to the interaction at an early stage of the coagulation cascade and neither to a direct inhibition of Factor Xa and IIa nor to an indirect effect mediated by antithrombin III.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTITHROMBIN-III; HEPARIN; POLYSACCHARIDES; ANTICOAGULANT DRUGS; HEPARINOIDS; LAMINARIN SULFATES, ANTICOAGULANT ACTIVITY |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54435 |
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