Carretero, Rafael and Sektioglu, Ibrahim M. and Garbi, Natalio and Salgado, Oscar C. and Beckhove, Philipp and Haemmerling, Guenter J. (2015) Eosinophils orchestrate cancer rejection by normalizing tumor vessels and enhancing infiltration of CD8(+) T cells. NATURE IMMUNOLOGY, 16 (6). 609-+. ISSN 1529-2908, 1529-2916
Full text not available from this repository. (Request a copy)Abstract
Tumor-associated eosinophilia is frequently observed in cancer. However, despite numerous studies of patients with cancer and mouse models of cancer, it has remained uncertain if eosinophils contribute to tumor immunity or are mere bystander cells. Here we report that activated eosinophils were essential for tumor rejection in the presence of tumor-specific CD8(+) T cells. Tumor-homing eosinophils secreted chemoattractants that guided T cells into the tumor, which resulted in tumor eradication and survival. Activated eosinophils initiated substantial changes in the tumor microenvironment, including macrophage polarization and normalization of the tumor vasculature, which are known to promote tumor rejection. Thus, our study presents a new concept for eosinophils in cancer that may lead to novel therapeutic strategies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VASCULAR NORMALIZATION; MYELOID CELLS; IMMUNOTHERAPY; MICE; INTERLEUKIN-4; DISEASE; HEALTH; GROWTH; TUMORIGENESIS; INFLAMMATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2019 13:54 |
| Last Modified: | 15 Jul 2019 13:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5444 |
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