BLASCHEK, W and KASBAUER, J and KRAUS, J and FRANZ, G (1992) PYTHIUM-APHANIDERMATUM - CULTURE, CELL-WALL COMPOSITION, AND ISOLATION AND STRUCTURE OF ANTITUMOR STORAGE AND SOLUBILIZED CELL-WALL (1 -] 3), (1 -] 6)-BETA-D-GLUCANS. CARBOHYDRATE RESEARCH, 231. pp. 293-307. ISSN 0008-6215,
Full text not available from this repository.Abstract
Under optimal conditions for the culture of the fungus Phytium aphanidermatum, no polysaccharides were excreted into the medium. The mycelium contained up to 38% of a slightly branched, storage (1 --> 3),(1 --> 6)-beta-D-glucan with a MW of 20000. The cell-wall polysaccharides of the mycelium comprised 18% of cellulose and 82% of (1 --> 3),(1 --> 6)-beta-D-glucans. Of the non-cellulosic glucans, approximately 33% could be solubilised by extraction with water at 121-degrees, and they had a MW of 10000, were highly branched, and contained 6% of (1 --> 6) linkages. Treatment of the cell wall with 0.1 M trifluoroacetic acid released approximately 50% of the non-cellulosic glucans. The acid-soluble cell-wall (1 --> 3),-(1 --> 6)-beta-D-glucans of lower MW (6000) were still highly branched and contained 14% of (1 --> 6) and 8% of (1 --> 4) linkages. The storage glucan and the hot-water-soluble cell-wall glucan exhibited strong activity against the Sarcoma 180 in CD-1 mice, whereas the acid-soluble cell-wall glucans were inactive. The hot-water-soluble cell-wall glucan was also active against the DBA/2-MC.SC-1 fibrosarcoma in DBA/2 mice.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHYTOPHTHORA-PALMIVORA; LENTINAN; POLYSACCHARIDES; GLUCANS; MYCOLAMINARANS; FUNGI; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54467 |
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