Lee, Stephanie J. and Wolff, Daniel and Kitko, Carrie and Koreth, John and Inamoto, Yoshihiro and Jagasia, Madan and Pidala, Joseph and Olivieri, Attilio and Martin, Paul J. and Przepiorka, Donna and Pusic, Iskra and Dignan, Fiona and Mitchell, Sandra A. and Lawitschka, Anita and Jacobsohn, David and Hall, Anne M. and Flowers, Mary E. D. and Schultz, Kirk R. and Vogelsang, Georgia and Pavletic, Steven (2015) Measuring Therapeutic Response in Chronic Graft-versus-Host Disease. National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IV. The 2014 Response Criteria Working Group Report. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 21 (6). pp. 984-999. ISSN 1083-8791, 1523-6536
Full text not available from this repository. (Request a copy)Abstract
In 2005, the National Institutes of Health (NIH) Chronic Graft-versus-Host Disease (GVHD) Consensus Response Criteria Working Group recommended several measures to document serial evaluations of chronic GVHD organ involvement. Provisional definitions of complete response, partial response, and progression were proposed for each organ and for overall outcome. Based on publications over the last 9 years, the 2014 Working Group has updated its recommendations for measures and interpretation of organ and overall responses. Major changes include elimination of several clinical parameters from the determination of response, updates to or addition of new organ scales to assess response, and the recognition that progression excludes minimal, clinically insignificant worsening that does not usually warrant a change in therapy. The response definitions have been revised to reflect these changes and are expected to enhance reliability and practical utility of these measures in clinical trials. Clarification is provided about response assessment after the addition of topical or organ-targeted treatment. Ancillary measures are strongly encouraged in clinical trials. Areas suggested for additional research include criteria to identify irreversible organ damage and validation of the modified response criteria, including in the pediatric population. Published by Elsevier Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STEM-CELL TRANSPLANTATION; SYSTEMIC-LUPUS-ERYTHEMATOSUS; BONE-MARROW-TRANSPLANTATION; CHRONIC GVHD CONSORTIUM; 6-MINUTE WALK TEST; OBLITERANS ORGANIZING PNEUMONIA; HUMAN ACTIVITY PROFILE; FAILURE-FREE SURVIVAL; SLEEP QUALITY INDEX; RHEUMATOID-ARTHRITIS; Chronic graft-versus-host disease; Allogeneic hematopoietic cell transplantation; Response criteria; Consensus; Guidelines |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2019 13:46 |
| Last Modified: | 15 Jul 2019 13:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5448 |
Actions (login required)
 |
View Item |
