LERUPPERT, K and MASTERS, JRW and KNUECHEL, R and SEEGERS, S and TAINSKY, MA and HOFSTAEDTER, F and BUETTNER, R (1992) THE EFFECT OF RETINOIC ACID ON CHEMOSENSITIVITY OF PA-1 HUMAN TERATOCARCINOMA CELLS AND ITS MODULATION BY AN ACTIVATED N-RAS ONCOGENE. INTERNATIONAL JOURNAL OF CANCER, 51 (4). pp. 646-651. ISSN 0020-7136,
Full text not available from this repository.Abstract
Combination of chemotherapeutic drugs with agents that induce cell differentiation is a possible means of improving cancer chemotherapy. To explore this approach we used 4 cell lines established from the human teratocarcinoma-derived cell line PA-1; 2 retinoic acid (RA)-sensitive lines compared to 2 RA-resistant lines transformed by an activated N-ras oncogene. Equal numbers of colony-forming cells were exposed for 72 hr to 10(-6) M RA and subsequently to a range of concentrations of cisplatinum, etoposide or bleomycin. Enhanced cytotoxicity of cisplatin and etoposide (3- to 5-fold) was observed in the N-ras-transformed cell lines compared to the non-transformed lines. Treatment with RA caused an increase in the cytotoxicity of all 3 drugs to the 2 RA-sensitive cell lines. In contrast, a reduction of cytotoxicity was observed in the 2 N-ras-transformed lines. Our results indicate that sensitivity to cytotoxic agents can be increased by RA in RA-sensitive cells, but the opposite effect is seen in N-ras transformed, RA-resistant cells. Therefore, a general rationale for combination therapy with RA and cytotoxic drugs cannot be inferred.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARCINOMA-CELLS; DIFFERENTIATION; CISPLATIN; TUMORS; HEAD; NECK; LINE; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54498 |
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