Schelker, Roland C. and Barreiros, Ana P. and Hart, Christina and Herr, Wolfgang and Jung, Ernst-Michael (2017) Macro- and microcirculation patterns of intrahepatic blood flow changes in patients with hereditary hemorrhagic telangiectasia. WORLD JOURNAL OF GASTROENTEROLOGY, 23 (3). pp. 486-495. ISSN 1007-9327, 2219-2840
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AIM To evaluated vascular dynamic processes in the liver of hereditary hemorrhagic telangiectasia (HHT) patients by ultrasound (US) considering quantitative analytic methods. METHODS The imaging features on US and contrast-enhanced ultrasound (CEUS) in 18 patients diagnosed with HHT were retrospectively analyzed. Regarding CEUS, real-time contrast harmonic imaging and sulfur hexafluoridefilled microbubbles were used. RESULTS HVaMs were identified in all 18 patients. By US, the two major Caselitz criteria could be detected in 55.6% patients. "Color spots" were detected in 72.2% of the cases. Respecting sonographic grading criteria by Buscarini, grade 3 could be demonstrated most frequent (40%). By CEUS, all the patients showed quick and early hyperenhancement during the arterial phase. Significant lowest time to peak (TTP) and highest area under the curve (AUC) values were identified in the hepatic artery (TTP: 69.8%; AUC: 100%) and highest TTP and lowest AUC in the hepatic parenchyma and the portal vein. CONCLUSION For the first time we analyzed CEUS findings of a group of HHT patients regarding macro- and microcirculation. Our data demonstrate significant differences in TTP and AUC values in the four selected regions: hepatic artery, shunt region, portal vein and hepatic parenchyma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTRAST-ENHANCED ULTRASOUND; OSLER-WEBER-SYNDROME; ROW HELICAL CT; HEPATIC INVOLVEMENT; LIVER INVOLVEMENT; HHT; MICROVASCULARIZATION; DIAGNOSIS; CRITERIA; DISEASE; Hereditary hemorrhagic telangiectasia; Intrahepatic shunts; Contrast-enhanced ultrasound; Time-intensity-curve |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 27 Feb 2019 16:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/545 |
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