KLIMM, J and BEIN, T and FROHLICH, D and TAEGER, K (1992) NITRIC-OXIDE (NO) - PHYSIOLOGICAL AND BIOCHEMICAL SIGNIFICANCE. ANASTHESIOLOGIE & INTENSIVMEDIZIN, 33 (5). pp. 115-123. ISSN 0170-5334,
Full text not available from this repository.Abstract
During the last decade the role of endothelium in the regulation of vascular tone has been extensivly investigated. One of the most powerful substances released by the endothelium, endothelium-derived relaxing factor (EDRF), has been identified as the small, labile, anorganic molecule nitric oxide (NO). This discovery has thrown new light on the mediation of endothelium-dependent relaxation as a general adaptive mechanism of the cardiovascular system during anesthesia and intensive care. In addition NO may also be synthesized in tissues and cells outside the blood vessel wall. This simple gas has a widespread role as a chemical messenger between and within cells The extent of transcellular communication is limited by the short half-life of NO. The biological significance of this rapid communication may be to signal the initiation of several localized complementary cellular responses. Thus NO has an influence on many physiological and pathophysiological reactions: the control of local vascular diameter, modulation of platelet behaviour, the response on immunological and inflammatory processes, hepatic protein synthesis and the mediation of synaptic excitations in the central and peripheral nervous system. This fundamental biological discovery will lead to new insights into the homeostasis of single organs and the organism. In this review, the results of basic research concerning functions of NO are presented. The implications in terms of potential novel treatments for different diseases will need further analysis. It can be predicted that new therapeutical approaches will find their applications.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; NITRIC OXIDE; ENDOTHELIUM; BLOOD VESSELS; BLOOD PLATELETS; NERVOUS SYSTEM; LIVER |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54542 |
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