ITTEL, TH and GRUBER, E and HEINRICHS, A and HANDT, S and HOFSTADTER, F and SIEBERTH, HG (1992) EFFECT OF FLUORIDE ON ALUMINUM-INDUCED BONE-DISEASE IN RATS WITH RENAL-FAILURE. KIDNEY INTERNATIONAL, 41 (5). pp. 1340-1348. ISSN 0085-2538,
Full text not available from this repository.Abstract
Aluminum (Al) accumulation in renal failure is an etiological factor in the pathogenesis of low turnover bone disease. Aluminum-induced impairment of mineralization has been related to a reduced extent of active bone-forming surface. The present study investigated the effect of fluoride, a potent stimulator of osteoblast number, on the toxicity of aluminum in rats with renal failure (Nx). Following a large parenteral aluminum load (3.2 mg/kg x day) over a period of nine weeks, bone histomorphometry of vertebral cancellous bone revealed a severe low-turnover osteodystrophy as evidenced by a fall in osteoblastic osteoid surfaces and mineral apposition rates. Concurrent administration of fluoride [20 mg/liter (F20) or 40 mg/liter (F40) supplied with the drinking water] resulted in a significant increase in the number of osteoblasts (Nx + Al + F40 vs. Nx + Al, 33.75 +/- 2.83 vs. 1.81 +/- 0.43 mm-1, P < 0.001) together with an overall reduced deposition of aluminum in bone (469.3 +/- 24.6 vs. 592.2 +/- 28.3-mu-g/g, P < 0.01). However, there was an increase in the fraction of osteoid surface exhibiting stainable aluminum at the bone-osteoid interface (70.7 +/- 7.1 vs. 44.3 +/- 6.0%, P < 0.005). Fluoride-exposed rats accumulated a significantly larger osteoid volume, suggesting an exacerbation of the osteomalacic lesion, and furthermore, dynamic histomorphometric parameters remained depressed. These results indicate that fluoride has a distinct effect on the pattern of aluminum deposition in bone. In addition, fluoride antagonizes the aluminum-induced reduction in osteoblast number but provides no amelioration of the impaired mineralization in aluminum-intoxicated rats. Thus, in this model a decrease in the extent of osteoblast surface does not account for the development of aluminum-related bone disease. Aluminum toxicity in the presence of fluoride may involve physical-chemical inhibition of mineralization or altered cellular activity of osteoblasts.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PARATHYROID-HORMONE; TRABECULAR BONE; UREMIC RATS; VITAMIN-D; HISTOMORPHOMETRY; OSTEODYSTROPHY; OSTEOMALACIA; CALCIUM; TISSUE; ENCEPHALOPATHY; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54558 |
Actions (login required)
 |
View Item |
