KEES, F and RAASCH, W and GROBECKER, H (1992) STRUCTURAL CHARACTERIZATION OF AN UNKNOWN METABOLITE OF CIPROFLOXACIN. ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 42-1 (4). pp. 570-575. ISSN 0004-4172,
Full text not available from this repository.Abstract
The chemical structure of an unknown metabolite of ciprofloxacin (CAS 85721-33-1) is characterized by means of reversed phase ion pair liquid chromatography, absorption and fluorescence spectroscopy, partition coefficients as well as chemical and enzymatic hydrolytic degradation. A chemical structure of the unknown metabolite is proposed: N-formyl-desethylenciprofloxacin. It can be formed as an intermediate in the oxidative degradation of ciprofloxacin via oxociprofloxacin to desethylen-ciprofloxacin, or it may be formed by conjugation of desethylenciprofloxacin with formic acid. The amounts found in plasma and urine of patients were in the range of desethylen-ciprofloxacin, i.e. about 1 % of the parent compound.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERFORMANCE LIQUID-CHROMATOGRAPHY; SUBSTITUTED PHENOTHIAZINE DRUGS; PARTITION-COEFFICIENTS; IDENTICAL METABOLITES; BIOLOGICAL-FLUIDS; BODY-FLUIDS; PHARMACOKINETICS; URINE; OFLOXACIN; SERUM; ANTIBIOTICS; CAS 85721-33-1; CIPROFLOXACIN, METABOLISM |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54582 |
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