Seitz, Helmut K. and Mueller, Sebastian and Hellerbrand, Claus and Liangpunsakul, Suthat (2015) Effect of chronic alcohol consumption on the development and progression of non-alcoholic fatty liver disease (NAFLD). HEPATOBILIARY SURGERY AND NUTRITION, 4 (3). pp. 147-151. ISSN 2304-3881, 2304-389X
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A number of epidemiologic studies show a protective effect of light to moderate daily alcohol consumption on the development of non-alcoholic fatty liver disease (NAFLD). Although these small amounts of ethanol may prevent fatty liver, they may also be a risk factor for other diseases such as breast and colon cancer. Those individuals who have underlying hepatic steatosis or non-alcoholic steatohepatitis (NASH) should not use ethanol chronically since the data available at present do not support a beneficial effect of alcohol in this situation. Especially overweight and obese individuals may be more susceptible towards alcohol even at moderate doses. Animal experiments show a negative effect of ethanol on liver histology in either dietary or genetic NASH models. In addition, patients with NASH reveal a significant increased risk for hepatocellular cancer (HCC) even with social alcohol consumption. Thus, subjects with underlying NASH should abstain from alcohol at any amounts.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DECREASED PREVALENCE; HEPATIC STEATOSIS; RISK-FACTORS; STEATOHEPATITIS; LIGHT; ASSOCIATION; MANAGEMENT; FIBROSIS; DRINKING; DIET; Alcohol; non-alcoholic fatty liver disease (NAFLD); non-alcoholic steatohepatitis (NASH) |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Aug 2020 06:24 |
| Last Modified: | 21 Aug 2020 06:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5459 |
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