SYNTHESIS AND ANTITUMOR-ACTIVITY OF SULFOALKYL DERIVATIVES OF CURDLAN AND LICHENAN

DEMLEITNER, S and KRAUS, J and FRANZ, G (1992) SYNTHESIS AND ANTITUMOR-ACTIVITY OF SULFOALKYL DERIVATIVES OF CURDLAN AND LICHENAN. CARBOHYDRATE RESEARCH, 226 (2). pp. 247-252. ISSN 0008-6215,

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Abstract

2-Sulfoethyl, 3-sulfopropyl, and 4-sulfobutyl derivatives of the (1 --> 3)-beta-D-glucan curdlan and the (1 --> 3/1 --> 4)-beta-D-glucan lichenan have been synthesised. The substituents are located mainly at positions 6. The curdlan derivatives strongly inhibited the growth of the Sarcoma 180 tumour, whereas the lichenan derivatives were inactive, indicating that a (1 --> 3)-linked beta-D-glucan backbone is essential for activity.

Item Type: Article
Uncontrolled Keywords: SCLEROTINIA-SCLEROTIORUM IFO-9395; SOLUBLE BRANCHED POLYSACCHARIDES;
Depositing User: Dr. Gernot Deinzer
Last Modified: 19 Oct 2022 08:44
URI: https://pred.uni-regensburg.de/id/eprint/54601

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