BERNHARDT, G and GUST, R and REILE, H and VOMORDE, HD and MULLER, R and KELLER, C and SPRUSS, T and SCHONENBERGER, H and BURGEMEISTER, T and MANNSCHRECK, A and RANGE, KJ and KLEMENT, U (1992) [1,2-BIS(2-HYDROXYPHENYL)ETHYLENEDIAMINE]DICHLOROPLATINUM(II), A NEW COMPOUND FOR THE THERAPY OF OVARIAN-CANCER .2. SYNTHESIS AND PRELIMINARY TESTING OF THE ENANTIOMERIC COMPLEXES. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 118 (3). pp. 201-208. ISSN 0171-5216,
Full text not available from this repository.Abstract
The enantiomeric [1,2-bis(2-hydroxyphenyl)ethylenediamine] dichloroplatinum(II) complexes were synthesized and their configuration assessed. A preliminary test in the cisplatin-resistant human NIH:OVCAR-3 ovarian cancer cell line, which was previously characterized by its sensitivity against several therapeutically used drugs, showed that both enantiomers produce cytocidal effects in a concentration of 2.5-mu-M. A difference between the enantiomers became evident from the faster onset of cytocidal activity of the S,S-configurated compound.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARCINOMA; CELLS; ANTITUMOR; CISPLATIN; GROWTH; DNA; (R,R)-[1,2-BIS(2-HYDROXYPHENYL)-ETHYLENEDIAMINE]DICHLOROPLATINUM(II); (S,S)-[1,2-BIS(2-HYDROXYPHENYL)-ETHYLENEDIAMINE]DICHLOROPLATINUM(II); NIH-OVCAR-3 OVARIAN CANCER CELL LINE; PRELIMINARY TESTING; SYNTHESIS |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54624 |
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