BERNHARDT, G and MULLER, R and GUST, R and REILE, H and KELLER, C and SPRUSS, T and SCHONENBERGER, H (1992) DICHLORO-[1-(HYDROXYPHENYL)-2-PHENYLETHYLENEDIAMINE]PLATINUM(II) COMPLEXES - TESTING ON THE HUMAN OVARIAN-CANCER CELL-LINES NIH - OVCAR-3 AND SK-OV-3. ARCHIV DER PHARMAZIE, 325 (2). pp. 93-99. ISSN 0365-6233,
Full text not available from this repository.Abstract
The diastereoisomeric dichloro-[1-(2-, 3- and 4-hydroxyphenyl)-2-phenylethylenediamine]platinum(II) complexes were tested on two human ovarian cancer cell lines NIH: OVCAR-3 and SK-OV-3, both resistant against cisplatin. Dichloro-[threo-1-(3-hydroxyphenyl)-2-phenylethylenediamine]platinum(II) (threo-5-PtCl2) proved to be the most active representative of the new series, producing cytocidal effects at a concentration range of 2.5 to 5.0-mu-M on the NIH: OVCAR-3 cell line. On the more resistant SK-OV-3 cell line, threo-5-PtCl2 was only moderately active, while in combination with BSO, a GSH level lowering compound, threo-5-PtCl2 showed a strong synergistic effect.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARCINOMA; CHEMOTHERAPY; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54649 |
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