Hautmann, Anke H. and Hautmann, Matthias G. and Koelbl, Oliver and Herr, Wolfgang and Fleck, Martin (2015) Tumor-Induced Osteomalacia: an Up-to-Date Review. CURRENT RHEUMATOLOGY REPORTS, 17 (6): 37. ISSN 1523-3774, 1534-6307
Full text not available from this repository. (Request a copy)Abstract
Tumor-induced osteomalacia (TIO) is a paraneoplastic syndrome resulting in renal phosphate wasting and decreased bone mineralization. TIO is usually induced by small, slowly growing tumors of mesenchymal origin (phosphaturic mesenchymal tumor mixed connective tissue variant [PMTMCT]). Nonspecific symptoms including fatigue, bone pain, and musculoskeletal weakness make the diagnosis elusive and often lead to a delay in treatment. The prognosis of TIO is excellent following complete resection of the neoplasm, which leads to the rapid and complete reversal of all symptoms. If the tumor cannot be detected, treatment relies on supplementation with phosphate and active vitamin D compounds. Subsequent radiotherapy in case of incompletely resected tumors or definitive radiotherapy in unresectable tumors is an important treatment option to avoid recurrence or metastasis even though this occurs rarely. Due to the risk of recurrence or late metastases, long-term monitoring is required even in TIO patients diagnosed with a benign tumor.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PHOSPHATURIC MESENCHYMAL TUMOR; GIANT-CELL TUMORS; OF-THE-LITERATURE; TERM-FOLLOW-UP; ONCOGENIC OSTEOMALACIA; RADIATION-THERAPY; BONE; HEMANGIOPERICYTOMA; RADIOTHERAPY; DIAGNOSIS; Tumor-induced osteomalacia; Paraneoplastic disorder; Hypophosphatemia; FGF23; Somatostatin receptor 2A; Phosphaturic mesenchymal tumor mixed connective tissue variant; Radiotherapy; Giant cell tumor; Hemangiopericytoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Röntgendiagnostik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Jul 2019 08:05 |
| Last Modified: | 15 Jul 2019 08:05 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5465 |
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