KRAUS, J and BLASCHEK, W and SCHUTZ, M and FRANZ, G (1992) ANTITUMOR-ACTIVITY OF CELL-WALL BETA-1,3/1,6-GLUCANS FROM PHYTOPHTHORA SPECIES. PLANTA MEDICA, 58 (1). pp. 39-42. ISSN 0032-0943,
Full text not available from this repository.Abstract
From the cell walls of various Phytophthora species (Oomycetes) different water-soluble beta-1,3/1,6-glucans were isolated and characterized. The glucans with relative molecular masses between 13 and 50 kd exhibited varying degrees of branching in the beta-1,3-linked glucan backbone ranging from 14 to 50%. The dose-dependent antitumor activity of the glucans against allogeneic sarcoma-180 was investigated. It could be demonstrated that beta-1,3/1,6-glucans with relative molecular masses below 50 kd can exhibit a prominent antitumor activity (inhibition rate up to 99%), being comparable to that of the high relative molecular mass (450 kd) beta-1,3/1,6-glucans. Biological activity of the glucans could be shown to be correlated with a low degree of branching. The most potent glucan with a degree of branching of 14% also was active against the syngeneic DBA/2-MC.SC-1 fibrosarcoma (inhibition rate up to 90%) and in combination with a suboptimum dose of diethylstilbestrol against Noble-Nb prostate carcinoma (inhibition rate up to 90%).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LENTINAN; POLYSACCHARIDES; PHYTOPHTHORA; CELL WALL GLUCANS; BETA-1,3/1,6-GLUCANS; ANTITUMOR ACTIVITY; SARCOMA-180; NOBLE-NB PROSTATE CARCINOMA; DBA/2-MC.SC-1 FIBROSARCOMA |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54669 |
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