JILG, W and BITTNER, R and BOCK, HL and CLEMENS, R and SCHATZL, H and SCHMIDT, M and ANDRE, FE and DEINHARDT, F (1992) VACCINATION AGAINST HEPATITIS-A - COMPARISON OF DIFFERENT SHORT-TERM IMMUNIZATION SCHEDULES. VACCINE, 10. S126-S128. ISSN 0264-410X, 1873-2518
Full text not available from this repository.Abstract
A total of 114 healthy young adults were immunized with hepatitis A vaccine using different vaccination schedules. Individuals received either a single dose (group 1), two doses given simultaneously (group 2), two doses at days 0 and 14 (group 3) or at days 0 and 28 (group 4), or three doses at days 0, 7 and 21 (group 5). Two weeks after a single dose, seroconversion rates between 77 and 85% were achieved (groups 1, 3, 4). All individuals immunized with two doses within two weeks (groups 2, 3, 5) had antibodies to hepatitis A vaccine (anti-HAV positive) by week 3; these participants also showed clearly higher mean anti-HA V values (geometric mean titres, GMTs) at this time than those individuals vaccinated only once. GMTs at week 8 were 560 IU/l in group 5, 236, 339 and 428 IU/l in groups 2-4 and 102 IU/l in group 1. Of participants with anti-HAV at week 8, 82 were again tested 4 months later; all were still seropositive. Ten individuals were tested during the first three weeks at 3-4 day intervals for anti-HA V immunoglobulin M (IgM); specific IgM responses were not detectable before day 10 but were present in eight of 10 vaccinees by day 14.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SERONEGATIVE VOLUNTEERS; IMMUNOGENICITY; SAFETY; HEPATITIS-A VACCINATION; RAPID IMMUNIZATION; IMMUNIZATION SCHEDULES; EARLY IMMUNE RESPONSE |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:44 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54741 |
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