SAEZ, JC and BERTHOUD, VM and KADLE, R and TRAUB, O and NICHOLSON, BJ and BENNETT, MVL and DERMIETZEL, R (1991) PINEALOCYTES IN RATS - CONNEXIN IDENTIFICATION AND INCREASE IN COUPLING CAUSED BY NOREPINEPHRINE. BRAIN RESEARCH, 568 (1-2). pp. 265-275. ISSN 0006-8993,
Full text not available from this repository.Abstract
Dye coupling was observed between pinealocytes in acutely dissected pineal glands of adult rats. Pinealocytes maintained in culture were also electrically coupled. Connexins 26 and 43 and their respective mRNAs were present but neither connexin32 nor its mRNA were detected. Pinealocytes expressed only connexin26 whereas connexin43 was confined to astrocytes. In 5-day-old cultures of pinealocytes the incidence of dye coupling and level of immunodetectable connexin26 were low, and both were increased by norepinephrine (NE). The increase in incidence of coupling was maximal at around 6 h after treatment and was prevented by inhibitors of protein or mRNA synthesis. NE-induced metabolic and electical synchronization mediated by gap junctions may favor melatonin secretion.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GAP-JUNCTION PROTEIN; IMMUNOHISTOCHEMICAL DEMONSTRATION; N-ACETYLTRANSFERASE; GLIAL-CELLS; S-ANTIGEN; KINASE-C; GLAND; LIVER; TISSUES; BRAIN; GAP JUNCTION; CONNEXIN; COUPLING; PINEALOCYTE; ASTROCYTE; NOREPINEPHRINE |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54756 |
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