TANZER, H and BRAUN, C and SEIDEL, M and WIEGREBE, W (1991) ANTHRALIN DERIVATIVES - INHIBITION OF 5-LIPOXYGENASE - ANTIPSORIATIC EFFICACY. ARCHIV DER PHARMAZIE, 324 (11). pp. 841-846. ISSN 0365-6233,
Full text not available from this repository.Abstract
Inhibition of 5-lipoxygenase by anthralin (1) and 41 derivatives is determined: the acids 38 and 39, the lactones 40-42 and 9-anthrone (8) are the most potent inhibitors, the lactone 41 reaching the efficacy of nordihydroguaiaretic acid (NDGA). The results were correlated with the hydrophilic/lipophilic balance of the test compounds and their clinical efficacy as far as known. There is no correlation between the ''minimum structure'' of Krebs and Schaltegger 7) concerning antipsoriatic activity and the inhibitory effects against 5-lipoxygenase.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERFORMANCE LIQUID-CHROMATOGRAPHY; ARACHIDONIC-ACID; HUMAN-NEUTROPHILS; DITHRANOL; PSORIASIS; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54798 |
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