BRUNNER, H and NERL, G and VONANGERER, E and KNEBEL, N (1991) ANTITUMOR-ACTIVE PLATINUM(II) COMPLEXES WITH SUBSTITUTED 2-AMINOMETHYLPYRIDINE LIGANDS. ARCHIV DER PHARMAZIE, 324 (10). pp. 779-784. ISSN 0365-6233,
Full text not available from this repository.Abstract
Reaction of K2PtCl4 with the substituted 2-aminomethylpyridines 9, 14, and 22 affords the corresponding dichloroplatinum(II) complexes 3-5. Compounds 3 and 22 show remarkable relative binding affinities for the estrogen receptor. Towards the hormone-independent P388-tumor of the CD2F1-mouse the platinum(II) complexes 4 and 5 are weakly active, complex 3 is inactive. Towards the hormone-independent MDA-MB 231-cell line, compounds 3-5, 9, 14, and 22 exhibit no significant antitumor activity. Towards the hormone-dependant MCF-7 cell line, compounds 3-5, 9, 14 show weak antitumor activity, whereas compound 22 exhibits strong inhibition.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEPENDENT MAMMARY-CARCINOMA; ESTROGEN-RECEPTOR; AFFINITY; TUMORS; AGENTS; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54827 |
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