HOLLER, E and SCHALLER, W and KEPPLER, B (1991) INHIBITION OF ESCHERICHIA-COLI DNA-POLYMERASE-I CATALYZED DNA POLYMERIZATION BY TRANS-IMIDAZOLIUM-BISIMIDAZOLETETRACHLORORUTHENATE(III). ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 41-2 (10). pp. 1065-1068. ISSN 0004-4172,
Full text not available from this repository.Abstract
The tumor-inhibiting metal complex trans-imidazolium-bisimidazoletetrachlororuthenate(III) (ICR) reacts with DNA and inhibits template-primer properties for DNA synthesis catalysed by Escherichia coli DNA polymerase I. The reaction with DNA depends on the aging (half-life 6.8 h) of the aqueous solution containing ICR. The kinetics of the reaction with DNA are reminiscent of those for cisplatin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANTITUMOR-ACTIVITY; DERIVATIVES; RUTHENIUM; CHEMOTHERAPEUTICS; DNA SYNTHESIS, INHIBITION; TRANS-IMIDAZOLIUM-BISIMIDAZOLETETRACHLORORUTHENATE(III) |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54829 |
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