WEBER, P and SCHEURLEN, M and WIEDMANN, KH (1991) PILOT-STUDY WITH METHOTREXATE IN THE TREATMENT OF PRIMARY BILIARY-CIRRHOSIS. DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 116 (36). pp. 1347-1352. ISSN 0012-0472, 1439-4413
Full text not available from this repository.Abstract
In a pilot study 5 females with primary biliary cirrhosis (PBC), histological stages I-III, were treated with methotrexate (7.5-15.0 mg by mouth weekly) for 15 months. Pruritus and fatigue decreased in 3 patients and cholestyramine could be reduced or discontinued. The concentration of alkaline phosphatase decreased significantly until the 6th month of treatment (P < 0.002), but only after the methotrexate dosage had been increased to 15 mg weekly. However, the improvement in cholestasis parameters persisted until the end of the period of observation in only 3 patients in stages I and II. In only one case, initially in stage III with increased serum bilirubin concentration of 3.5 mg/dl, was there a change in the histological stage, to stage IV, after treatment. These preliminary results indicate that methotrexate can influence the symptoms and cholestasis enzymes in the early stages of PBC. Controlled studies should therefore only be conducted on anicteric patients in an early stage of the disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RHEUMATOID-ARTHRITIS; CONTROLLED TRIAL; LIVER; THERAPY; FEATURES; DISEASE; PBC; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54868 |
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