GROSS, P and KOPPENHAGEN, K and WUDEL, E and BURGER, KJ and WELZEL, D and DISTLER, GA (1991) HEMODYNAMIC-EFFECTS OF ISRADIPINE AND NIFEDIPINE IN HYPERTENSION. ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 41-2 (9). pp. 910-912. ISSN 0004-4172,
Full text not available from this repository.Abstract
Hemodynamic Effects of Isradipine and Nifedipine in Hypertension Myocardial wall tension is an important determinant of the oxygen demand, the function and the degree of hypertrophy of the left ventricle. Myocardial wall tension should be influenced more favourably by a non-cardiodepressive antihypertensive than by a potentially cardiodepressive one. Therefore, we investigated the effects of an intravenous infusion of the calcium antagonists isradipine (I; 0.4 mg; 3,5- pyridinecarboxylic acid, 4- [benzofurazanyl]-1,4-dihydro-2,6-dimethyl-,methyl-ethylester[9CI]; CAS75695-93-1) and nifedipine (N; 2.0 mg) resp., on hemodynamics and myocardial wall tension in 12 hypertensives by an intraindividual comparison. The adrenergic reflex activation induced by vasodilatation was limited by pre-medication with 0.1 mg propranolol/kg body weight (i.v.) before application of I and N. Baseline blood pressure of the patients and its changes in response to both calcium antagonists were statistically comparable, as were the left ventricular end-diastolic volumes. The end-systolic volumes, however, decreased significantly on I but not on N: before I: 69 +/- 7.0 (mean +/- standard error), after I: 61 +/- 6.1 ml, 2p < 0,001; before N: 62 +/- 6.1, after N: 64 +/- 7.0 ml, n.s. (difference to I: 2 p < 0.05). Stroke volume increased only on I (before I: 62 +/- 4.1, after I: 69 +/- 4.1 ml, 2p < 0.001; before N: 64 +/- 3.5, after N: 65 +/- 3.8 ml, n.s. (difference to I: 2p < 0.05)). Corresponding changes were calculated for ejection fraction: before I: 48 +/- 2.3, after I: 54 +/- 2.3%, 2p < 0.001; before N: 52 +/- 2.0, after N: 52 +/- 2.3 %, n.s. (difference between medications 2p < 0.05). Systolic wall tension of the left ventricle decreased significantly more on I (before: 2767 +/- 231, after: 2153 +/- 162 rel. un., 2p < 0.001) than on N (before: 2636 +/- 212, after: 2310 +/- 199 rel. un; 2p < 0.05 (difference between medications 2p < 0.05)). The results point to significantly greater unloading of the heart in response to isradipine as compared to nifedipine.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DILTIAZEM; EXERCISE; CALCIUM ANTAGONISTS; CAS-75695-93-1; HYPERTENSION; ISRADIPINE; CLINICAL STUDIES; NIFEDIPINE |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54875 |
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