DANNHARDT, G and MEINDL, W and SCHOBER, BD and KAPPE, T (1991) ANTIMYCOBACTERIAL 4-HYDROXY-3-PHENYLPYRIDIN-2(1H)-ONES. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 26 (6). pp. 599-604. ISSN 0223-5234,
Full text not available from this repository.Abstract
4-Hydroxy-3-phenylpyridin-2 (1H)-ones with different substituents either at N-1 or in the phenyl group were synthesized by reaction of ethyl-beta-aminocrotonates with dialkyl malonates or 'magic malonates' (2,4,6-trichlorophenyl malonates). The evaluation of these compounds on Mycobacterium tuberculosis H37Ra, Escherichia coli B and Staphylococcus aureus ATCC 25923 showed significant inhibitory effects on M tuberculosis (5g and 5s, MIC = 8-mu-g/ml). A structure-activity relationship is discussed.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MALONYLHETEROCYCLES; PYRIDIN-2(1H)-ONES; ANTIMYCOBACTERIAL ACTIVITY |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54891 |
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