MULLER, BM and ROSSKOPF, F and PAPER, DH and KRAUS, J and FRANZ, G (1991) POLYSACCHARIDES FROM NERIUM OLEANDER - STRUCTURE AND BIOLOGICAL-ACTIVITY. PHARMAZIE, 46 (9). pp. 657-663. ISSN 0031-7144,
Full text not available from this repository.Abstract
A water extraction of crushed leaves of Nerium oleander yielded 2.3% of a crude polysaccharide, The main fraction (67%) represents a pectic polysaccharide mainly composed of galacturonic acid besides rhamnose, arabinose and galactose. The polysaccharide structure was characterized by NMR, mild acid- and pectinase treatment combined with GC-MS analyses. In vivo tests for a possible antitumor activity did not result in a significant action. Investigation of immunomodulating activity brought some indications for mitogenic activity and a weak macrophage-mediated cytotoxicity. Increase of phagocytosis could not be doubtlessly assigned to the polysaccharide due to the high amount of endotoxin in the homogenous fraction OLE 2.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54897 |
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