HERRMANN, W and BIERMANN, J and HANF, S and LINDHOFER, HG and KOSTNER, GM and BEITZ, J and REUTER, W (1991) FISH OIL DIET WITH HIGH N-3 PUFA LEVELS FOR CARDIOVASCULAR PATIENTS-EFFECTS ON SERUM CONCENTRATIONS OF LIPIDS, LP(A), FIBRINOLYSIS, AND BLOOD-PRESSURE. ZEITSCHRIFT FUR KLINISCHE MEDIZIN-ZKM, 46 (19). pp. 1363-1369. ISSN 0233-1608,
Full text not available from this repository.Abstract
The influence of dietary supplementation with n-3 fatty acids on serum lipids, apolipoproteins, coagulation and fibrinolytic parameters as well as the blood pressure was doppelblind studied. 35 coronary patients were treated during hospitalization for 4 weeks with 12 g fish oil concentrate per day (approx. 8.5 g n-3 fatty acids) in combination with a 5000 kJ 30% fat diet and moderate exercise. A control group of indetical patients (n = 18) was treated with 12 g/d of rape seed oil capsules of the some shape. The blood check and the submaximum bicycle ergometric exercise were carried out before and at the end of the therapy. The results can be summarized as follows: 1. Total cholesterol, LDL-cholesterol and apolipoprotein B fell significantly in both groups. HDL-cholesterol increased and triglycerides decreased significantly only in the fish oil group. 2. Plasma Lp(a) levels were reduced by 14% in the fish oil group but unaffected in the rape seed oil group. 3. The patients treated with fish oil could be categorized into two subgroups: a. "responders" exhibiting a reduction of Lp(a) by 24% and b. non-responders showing a non-significant rise by some 8% 4. The responders seemed to differ from non-responders by a greater reduction of apolipoprotein B and LDL-cholesterol as well as a stronger increase of HDL- especially HDL3-cholesterol. 5. There was a significant reduction of tissue plasminogen activator in the fish oil group, which correlated significantly with the reduction in Lp(a). Platelet number and aggregation behaviour were not significantly changed in either group. 6. There was a significant decrease of systolic and diastolic blood pressure by 6-7% in rest, in load as well as in the recovery phase at the end of the fish oil diet in contrast to the rape seed oil treated control patients without changes of blood pressure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54904 |
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