WEIMAR, C and VONANGERER, S and WIEGREBE, W (1991) METHOXY-8-OXOBERBINES AND ACETOXY-8-OXOBERBINES - SYNTHESIS, ANTITUMOR-ACTIVITY, AND INTERACTION WITH DNA. ARCHIV DER PHARMAZIE, 324 (8). pp. 509-518. ISSN 0365-6233,
Full text not available from this repository.Abstract
Most of the methoxy-8H-dibenzo[a,g]isoquinolin-8-ones 3a-h and their acetoxy derivatives 6a-e were synthesized by condensation of 1-oxo-1,2,3,4-tetrahydroisoquinolines 4a-c and homophthalic acid anhydrides 5a and b, ether cleavage and acetylation. These protoberberinones were tested for cytostatic activity in vitro using MDA-MB-231 mammary tumor cells and for interaction with native calf thymus DNA. Tetramethoxy-8-oxoberbine 3f shows an inhibition of cell proliferation of 87% at a concentration of 10(-5) mole; its cytostatic effect does not depend on intercalation into DNA.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ENAMIDE PHOTOCHEMISTRY; INTERCALATION; ACIDS; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54923 |
Actions (login required)
 |
View Item |
