KEES, F and LUKASSEK, U and NABER, KG and GROBECKER, H (1991) COMPARATIVE INVESTIGATIONS ON THE BIOAVAILABILITY OF CEFUROXIME AXETIL. ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 41-2 (8). pp. 843-846. ISSN 0004-4172,
Full text not available from this repository.Abstract
In a three-way cross-over study the bioavailability of cefuroxime was determined in 12 healthy volunteers after oral administration of 250 mg as cefuroxime axetil (Elobact(R); CAS 64544-07-6) in a plain aqueous suspension and as tablets from different batches. The tablet formulations showed nearly identical pharmacokinetic parameters and were bioequivalent. The mean maximum serum concentration was 4.7-mu-g/ml, achieved after 2.1 h. The serum half-live was 1.2-14 h, the area under the serum concentration-time curve was 14.3-14.4-mu-g/ml . h and the urinary recovery of unchanged cefuroxime was 54%. The bioavailability of cefuroxime after administration of cefuroxime axetil in aqueous suspensin was lower, but bio-inequivalence was not demonstrated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BETA-LACTAM ANTIBIOTICS; BRUSH-BORDER MEMBRANE; ORALLY ACTIVE CEPHALOSPORIN; PHOSPHATE BUFFER SOLUTION; PIVALOYLOXYMETHYL ESTERS; INTESTINAL-ABSORPTION; TRANSPORT MECHANISMS; CHEMICAL-STABILITY; DIPEPTIDES; VESICLES; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/54924 |
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