LASKE, R and SCHONENBERGER, H and HOLLER, E (1991) INVESTIGATIONS ON THE ANTIPROLIFERATIVE EFFECTS OF AMINO-ACID ANTAGONISTS TARGETING FOR AMINOACYL-TRANSFER RNA-SYNTHETASES .3. COMBINATION EXPERIMENTS. ARCHIV DER PHARMAZIE, 324 (3). pp. 153-160. ISSN 0365-6233,
Full text not available from this repository.Abstract
The combined effects of amino acid antagonists with proven or potential inhibitory activities on aminoacyl-tRNA synthetases were investigated on the murine leukemic cell line P388 D1. As the best result a summation of the antiproliferative effects was observed. Combinations with established cytostatic agents like platinum complexes or other antitumor compounds also yielded partly additive effects. In experiments performed with asparaginase L-aspartic acid-beta-hydroxamate gave synergistic growth inhibition of P388 D1 cells in vitro, which was reflected by additive effects against murine leukemia P388 in vivo.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CISPLATIN CYTO-TOXICITY; GLUTAMINE ANTAGONISTS; CELLS; AGENTS; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/55057 |
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