DHOPLE, AM and STRONG, LC and MEINDL, W and SCHOENENBERGER, H and GARDNER, GD (1991) INVITRO AND INVIVO EFFECTS OF N-METHYL-3,5-DICHLORO-BENZYLAMINE HYDROCHLORIDE ON MYCOBACTERIUM-LEPRAE. ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 41-1 (3). pp. 253-256. ISSN 0004-4172,
Full text not available from this repository.Abstract
The antimicrobial effects of a new benzylamine, ME-93 (N-methyl-3,5-dichloro-benzylamine hydrochloride), alone and in combination with dapsone and rifampicin, have been evaluated in vitro in cell-free culture system and in vivo in mouse foot pad system. Even at 50-mu-g/ml, ME-93 did not completely inhibit the in vitro growth of M. leprae, and the effects were bacteriostatic. However, there was a synergism when ME-93 was combined with rifampicin, and the effects were bactericidal. Similar findings were also obtained in the mouse foot pad system. Thus, there is a new drug that needs further attention in the chemotherapy of leprosy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RIFAMPIN-RESISTANT LEPROSY; ADENOSINE-TRIPHOSPHATE; VIABILITY; SCREEN; ANTILEPROSY DRUGS; DAPSONE; ME-93; N-METHYL-3,5-DICHLORO-BENZYLAMINE HYDROCHLORIDE, INVITRO AND INVIVO STUDIES; MYCOBACTERIUM LEPRAE; RIFAMPICIN |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/55059 |
Actions (login required)
 |
View Item |
