Grassmann, Felix and Fleckenstein, Monika and Chew, Emily Y. and Strunz, Tobias and Schmitz-Valckenberg, Steffen and Goebel, Arno P. and Klein, Michael L. and Ratnapriya, Rinki and Swaroop, Anand and Holz, Frank G. and Weber, Bernhard H. F. (2015) Clinical and Genetic Factors Associated with Progression of Geographic Atrophy Lesions in Age-Related Macular Degeneration. PLOS ONE, 10 (5): e0126636. ISSN 1932-6203,
Full text not available from this repository. (Request a copy)Abstract
Worldwide, age-related macular degeneration (AMD) is a serious threat to vision loss in individuals over 50 years of age with a pooled prevalence of approximately 9%. For 2020, the number of people afflicted with this condition is estimated to reach 200 million. While AMD lesions presenting as geographic atrophy (GA) show high inter-individual variability, only little is known about prognostic factors. Here, we aimed to elucidate the contribution of clinical, demographic and genetic factors on GA progression. Analyzing the currently largest dataset on GA lesion growth (N = 388), our findings suggest a significant and independent contribution of three factors on GA lesion growth including at least two genetic factors (ARMS2_rs10490924 [P < 0.00088] and C3_rs2230199 [P < 0.00015]) as well as one clinical component (presence of GA in the fellow eye [P < 0.00023]). These correlations jointly explain up to 7.2% of the observed inter-individual variance in GA lesion progression and should be considered in strategy planning of interventional clinical trials aimed at evaluating novel treatment options in advanced GA due to AMD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISEASE PROGRESSION; NATURAL-HISTORY; MESSENGER-RNA; EYE DISEASE; FACTOR-H; COMPLEMENT; RISK; AMD; ARMS2; NEUROGENESIS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Humangenetik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Jul 2019 08:51 |
| Last Modified: | 18 Jul 2019 08:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5508 |
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