MULLER, R and SCHICKANEDER, E and JENNERWEIN, M and REILE, H and SPRUSS, T and ENGEL, J and SCHONENBERGER, H (1991) TUMOR-INHIBITING [1,2-BIS(DIFLUOROPHENYL)ETHYLENEDIAMINE]-DICHLOROPLATINUM(II) COMPLEXES .1. SYNTHESIS. ARCHIV DER PHARMAZIE, 324 (2). pp. 115-120. ISSN 0365-6233,
Full text not available from this repository.Abstract
The synthesis of the diastereomeric 1,2-bis(2,3-, 2,4-, 2,5-, 2,6-, 3,4-, 3,5-difluorophenyl)ethylenediamines (meso, D/L 8-13) from meso 1,2-bis(2-hydroxyphenyl)ethylenediamine and the respective difluorobenzaldehyde by a diaza-Cope-rearrangement and their conversion into the [1,2-bis(2,3-, 2,4-, 2,5-, 2,6-, 3,4-, 3,5-difluorophenyl)ethylenediamine]dihaloplatinum(II)-complexes (meso, D/L 8-13 PtCl2; meso D/L 9- and 11-PtI2) with K2PtHal4 (Hal = Cl, I) is described. From the diiodoplatinum(II)-complexes (meso D/L 9- and 11-PtI2) the better water soluble diaqua[1,2-bis(2,4- and 2,6-diffluorophenyl)ethylenediamine]platinum(II) sulfates (meso, D/L 9- and 11-PtSO4) are obtained by reaction with Ag2SO4.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RING; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/55087 |
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