AOUADI, S and HEYRAUD, A and SEIGLEMURANDI, F and STEIMAN, R and KRAUS, J and FRANZ, G (1991) STRUCTURE AND PROPERTIES OF AN EXTRACELLULAR POLYSACCHARIDE FROM LAETISARIA-ARVALIS - EVALUATION OF ITS ANTITUMOR-ACTIVITY. CARBOHYDRATE POLYMERS, 16 (2). pp. 155-165. ISSN 0144-8617,
Full text not available from this repository.Abstract
A polysaccharide isolated from the culture filtrate of Laetisaria arvalis (Basidiomycete) has been submitted to acid hydrolysis, periodate oxidation, Smith degradation, methylation analysis, and treatment with endo-(1 --> 3)-beta-D-glucanase. A 6-O-branched (1 --> 3)-beta-D-glucan with a structure similar to that of scleroglucan has been identified. In aqueous solution, this polysaccharide develops high viscosities and shows pseudoplastic behaviour. Increasing NaOH concentration reduces viscosity, which is due to a similar conformational transition to that found for scleroglucan. The antitumour activity of the glucan was tested against solid Sarcoma-180 in mice. The polysaccharide strongly inhibited tumour growth with an inhibition ratio of almost 100%.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SCLEROGLUCAN; |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:46 |
| URI: | https://pred.uni-regensburg.de/id/eprint/55119 |
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