Weiskirchen, Ralf and Mahli, Abdo and Weiskirchen, Sabine and Hellerbrand, Claus (2015) The hop constituent xanthohumol exhibits hepatoprotective effects and inhibits the activation of hepatic stellate cells at different levels. FRONTIERS IN PHYSIOLOGY, 6: 140. ISSN 1664-042X
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Xanthohumol is the principal prenylated flavonoid of the female inflorescences of the hop plant. In recent years, various beneficial xanthohumol effects including anti-inflammatory, antioxidant, hypoglycemic activities, and anticancer effects have been revealed. This review summarizes present studies indicating that xanthohumol also inhibits several critical pathophysiological steps during the development and course of chronic liver disease, including the activation and pro-fibrogenic genotype of hepatic stellate cells. Also the various mechanism of action and molecular targets of the beneficial xanthohumol effects will be described. Furthermore, the potential use of xanthohumol or a xanthohumol-enriched hop extract as therapeutic agent to combat the progression of chronic liver disease will be discussed. It is notable that in addition to its hepatoprotective effects, xanthohumol also holds promise as a therapeutic agent for treating obesity, dysregulation of glucose metabolism and other components of the metabolic syndrome including hepatic steatosis. Thus, therapeutic xanthohumol application appears as a promising strategy, particularly in obese patients, to inhibit the development as well as the progression of non-alcoholic fatty liver disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FATTY LIVER-DISEASE; HUMULUS-LUPULUS L.; PERFORMANCE LIQUID-CHROMATOGRAPHY; TOXIN-INDUCED HEPATOTOXICITY; ISCHEMIA-REPERFUSION INJURY; TANDEM MASS-SPECTROMETRY; IN-VITRO; HEPATOCELLULAR-CARCINOMA; NONALCOHOLIC STEATOHEPATITIS; C VIRUS; xanthohumol; hops; fibrosis; hepatic stellate cells; liver disease |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Aug 2020 05:24 |
| Last Modified: | 21 Aug 2020 05:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5512 |
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