ANTIBIOTICS FROM BASIDIOMYCETES .37. NEW INHIBITORS OF CHOLESTEROL-BIOSYNTHESIS FROM CULTURES OF XERULA-MELANOTRICHA DORFELT

KUHNT, D and ANKE, T and BESL, H and BROSS, M and HERRMANN, R and MOCEK, U and STEFFAN, B and STEGLICH, W (1990) ANTIBIOTICS FROM BASIDIOMYCETES .37. NEW INHIBITORS OF CHOLESTEROL-BIOSYNTHESIS FROM CULTURES OF XERULA-MELANOTRICHA DORFELT. JOURNAL OF ANTIBIOTICS, 43 (11). pp. 1413-1420. ISSN 0021-8820,

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Abstract

Three new inhibitors of cholesterol biosynthesis have been isolated from cultures of Xerula melanotricha and their structures elucidated by spectroscopic methods. Dihydroxerulin (1) in admixture with xerulin (2) strongly inhibits the incorporation of C-14- acetate into cholesterol in HeLa cells while the incorporation of C-14-mevalonate is not affected. Xerulinic acid (3) shows similar biological activities but a higher cytotoxicity.

Item Type:	Article
Uncontrolled Keywords:	CYTOPLASMIC 3-HYDROXY-3-METHYLGLUTARYL COENZYME; SYNTHASE; METABOLITES; CELLS;
Depositing User:	Dr. Gernot Deinzer
Last Modified:	19 Oct 2022 08:48
URI:	https://pred.uni-regensburg.de/id/eprint/55234

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