Pallesen, Lars-Peder and Gerber, Johannes and Dzialowski, Imanuel and van der Hoeven, Erik J. R. J. and Michel, Patrik and Pfefferkorn, Thomas and Ozdoba, Christoph and Kappelle, L. Jaap and Wiedemann, Baerbel and Khomenko, Andrei and Algra, Ale and Hill, Michael D. and von Kummer, Ruediger and Demchuk, Andrew M. and Schonewille, Wouter J. and Puetz, Volker (2015) Diagnostic and Prognostic Impact of pc-ASPECTS Applied to Perfusion CT in the Basilar Artery International Cooperation Study. JOURNAL OF NEUROIMAGING, 25 (3). pp. 384-389. ISSN 1051-2284, 1552-6569
Full text not available from this repository. (Request a copy)Abstract
BACKGROUND AND PURPOSEThe posterior circulation Acute Stroke Prognosis Early CT Score (pc-APECTS) applied to CT angiography source images (CTA-SI) predicts the functional outcome of patients in the Basilar Artery International Cooperation Study (BASICS). We assessed the diagnostic and prognostic impact of pc-ASPECTS applied to perfusion CT (CTP) in the BASICS registry population. METHODSWe applied pc-ASPECTS to CTA-SI and cerebral blood flow (CBF), cerebral blood volume (CBV), and mean transit time (MTT) parameter maps of BASICS patients with CTA and CTP studies performed. Hypoattenuation on CTA-SI, relative reduction in CBV or CBF, or relative increase in MTT were rated as abnormal. RESULTSCTA and CTP were available in 27/592 BASICS patients (4.6%). The proportion of patients with any perfusion abnormality was highest for MTT (93%; 95% confidence interval [CI], 76%-99%), compared with 78% (58%-91%) for CTA-SI and CBF, and 46% (27%-67%) for CBV (P < .001). All 3 patients with a CBV pc-ASPECTS < 8 compared to 6/23 patients with a CBV pc-ASPECTS 8 had died at 1 month (RR 3.8; 95% CI, 1.9-7.6). CONCLUSIONCTP was performed in a minority of the BASICS registry population. Perfusion disturbances in the posterior circulation were most pronounced on MTT parameter maps. CBV pc-ASPECTS < 8 may indicate patients with high case fatality.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ANGIOGRAPHY SOURCE IMAGES; ACUTE ISCHEMIC-STROKE; INTRAARTERIAL THROMBOLYSIS; COMPUTED-TOMOGRAPHY; RANDOMIZED-TRIAL; INFARCT CORE; OCCLUSION; MRI; RECANALIZATION; ALTEPLASE; CT perfusion; basilar artery occlusion; pc-ASPECTS |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 19 Jul 2019 13:11 |
| Last Modified: | 19 Jul 2019 13:11 |
| URI: | https://pred.uni-regensburg.de/id/eprint/5577 |
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