Vornefeld, Michael and Huber, Friedo and Preut, Hans and Brunner, Henri (1989) Synthesis and spectroscopic characterization of dimethylgermanium derivatives of dipeptides, crystal structure of dimethylgermanium glycylglycinate and in vivo effects of dimethylgermanium glycylglycinate against murine leukemia P388. APPLIED ORGANOMETALLIC CHEMISTRY, 3 (2). pp. 177-182. ISSN 0268-2605, 1099-0739
Full text not available from this repository.Abstract
Dimethylgermanium derivatives of dipeptides, Me(2)GeAA (H(2)AA = H(2)glygly, H(2)glyala, H(2)glyval, H(2)glyleu, H(2)glymet) have been obtained by the reaction of Me2GeBr2 with H(2)AA in the presence of triethylamine. The crystal structure of Me(2)Geglygly has been determined by single-crystal X-ray diffraction. The dipeptide is tridentately coordinated to germanium, which has a distorted trigonal bipyramidal environment. From infrared and Raman data, analogous molecular structures are inferred for the other dimethylgermanium derivatives of dipeptides. H-1 NMR measurements show that Me(2)Geglygly is completely hydrolyzed in aqueous solution to give H(2)glygly and (Me2GeO)(x). In vivo tests with Me(2)Geglygly showed no toxic or antitumor activity against murine leukemia P388.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; Organogermanium; dipeptide; structure; toxicity |
| Depositing User: | Dr. Gernot Deinzer |
| Last Modified: | 19 Oct 2022 08:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/55985 |
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