Glehr, Gunther and Riquelme, Paloma and Yang Zhou, Jordi and Cordero, Laura and Schilling, Hannah-Lou and Kapinsky, Michael and Schlitt, Hans J. and Geissler, Edward K. and Burkhardt, Ralph and Schmidt, Barbara and Haferkamp, Sebastian and Hutchinson, James A. and Kronenberg, Katharina (2022) External validation of biomarkers for immune-related adverse events after immune checkpoint inhibition. FRONTIERS IN IMMUNOLOGY, 13: 1011040. ISSN 1664-3224,
Full text not available from this repository. (Request a copy)Abstract
Immune checkpoint inhibitors have revolutionized treatment of advanced melanoma, but commonly cause serious immune-mediated complications. The clinical ambition of reserving more aggressive therapies for patients least likely to experience immune-related adverse events (irAE) has driven an extensive search for predictive biomarkers. Here, we externally validate the performance of 59 previously reported markers of irAE risk in a new cohort of 110 patients receiving Nivolumab (anti-PD1) and Ipilimumab (anti-CTLA-4) therapy. Alone or combined, the discriminatory value of these routine clinical parameters and flow cytometry biomarkers was poor. Unsupervised clustering of flow cytometry data returned four T cell subsets with higher discriminatory capacity for colitis than previously reported populations, but they cannot be considered as reliable classifiers. Although mechanisms predisposing some patients to particular irAEs have been described, we are presently unable to capture adequate information from pre-therapy flow cytometry and clinical data to reliably predict risk of irAE in most cases.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADVANCED MELANOMA; BLOOD-COUNT; IPILIMUMAB; TOXICITY; REGULARIZATION; AUTOIMMUNITY; THERAPY; biomarker; checkpoint inhibition; irAEs; immune-related adverse events; validation; prediction |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Dermatologie und Venerologie Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 12 Feb 2024 10:56 |
| Last Modified: | 12 Feb 2024 10:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56497 |
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