Ghimire, Sakhila and Ederer, Katharina U. and Meedt, Elisabeth and Weber, Daniela and Matos, Carina and Hiergeist, Andreas and Zeman, Florian and Wolff, Daniel and Edinger, Matthias and Poeck, Hendrik and Herr, Wolfgang and Gessner, Andre and Holler, Ernst and Buelow, Sigrid (2022) Low Intestinal IL22 Associates With Increased Transplant-Related Mortality After Allogeneic Stem Cell Transplantation. FRONTIERS IN IMMUNOLOGY, 13: 857400. ISSN 1664-3224,
Full text not available from this repository. (Request a copy)Abstract
The role of IL-22 in adult patients undergoing allogeneic stem cell transplantation (SCT) is of major interest since animal studies showed a protective and regenerative effect of IL-22 in graft versus host disease (GvHD). However, no clinical data exist on the tissue expression. Here we demonstrate that patients not suffering from transplant-related mortality (TRM) show significantly upregulated IL22 expression during histological and clinical GI-GvHD (p = 0.048 and p = 0.022, respectively). In contrast, in GvHD patients suffering from TRM, IL22 was significantly lower (p = 0.007). Accordingly, lower IL22 was associated with a higher probability of TRM in survival analysis (p = 0.005). In a multivariable competing risk Cox regression analysis, low IL22 was identified as an independent risk factor for TRM (p = 0.007, hazard ratio 2.72, 95% CI 1.32 to 5.61). The expression of IL22 seemed to be microbiota dependent as broad-spectrum antibiotics significantly diminished IL22 expression (p = 0.019). Furthermore, IL22 expression significantly correlated with G-protein coupled receptor (GPR)43 (r = 0.263, p = 0.015) and GPR41 expression (r = 0.284, p = 0.009). In conclusion, our findings reveal an essential role of IL-22 for the prognosis of patients undergoing allogeneic SCT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; INDUCIBLE FACTOR; RISK; CLONING; IL-22; GUIDE; GVHD; IL22; allogeneic SCT; GvHD; TRM; antibiotics; GPR41; GPR43 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 30 Oct 2023 09:51 |
| Last Modified: | 30 Oct 2023 09:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56515 |
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