Allgaier, Raphael and Strack, Christina and Wallner, Stefan and Hubauer, Ute and Uecer, Ekrem and Lehn, Petra and Keyser, Andreas and Luchner, Andreas and Maier, Lars and Jungbauer, Carsten (2022) NAG: potential cardiorenal biomarker indicates progression of chronic kidney disease in implantable cardioverter defibrillator patients, contrary to KIM-1. BIOMARKERS IN MEDICINE, 16 (4). pp. 265-275. ISSN 1752-0363, 1752-0371
Full text not available from this repository. (Request a copy)Abstract
Aim: NAG and KIM-1 as markers of tubular damage are suggested as potential biomarkers for the cardiorenal syndrome. Aim of the study was to assess the prognostic capability of NAG and KIM-1 regarding progression of chronic kidney disease (CKD) in patients with implantable cardioverter defibrillator (ICD). Materials & methods: We included 313 patients with an ICD and collected plasma and urine samples. Follow-up was performed after 51 months (interquartile range [IQR]: 25-55). Outcome of interest was continuous CKD progression defined as persistent decline in estimated glomerular filtration rate category accompanied by a >= 25% drop of baseline estimated glomerular filtration rate. Results: Average four (IQR: 2-6) follow-up values of serum creatinine per patient were obtained. During followup 29 patients (9%) developed a continuous CKD progression. NAG was shown as independent predictor for continuous CKD progression (p = 0.01), opposite to KIM-1 (p = n.s.). Conclusion: NAG was shown as predictor for a progressive and real deterioration of kidney function in patients with ICD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BETA-D-GLUCOSAMINIDASE; WORSENING RENAL-FUNCTION; SUDDEN CARDIAC DEATH; HEART-FAILURE; TUBULAR DAMAGE; INJURY MOLECULE-1; ESC GUIDELINES; IMPAIRMENT; ASSOCIATION; DIAGNOSIS; cardiorenal syndrome; chronic heart failure; CKD progression; NAG; tubular markers |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Oct 2023 06:03 |
| Last Modified: | 31 Oct 2023 06:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56532 |
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