Ivanova, Irina and Svilenska, Teodora and Kurz, Bernadett and Grobecker, Sonja and Maisch, Tim and Berneburg, Mark and Kamenisch, York (2022) Improved Spectral Purity of 222-nm Irradiation Eliminates Detectable Cyclobutylpyrimidine Dimers Formation in Skin Reconstructs even at High and Repetitive Disinfecting Doses. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 98 (5). pp. 1149-1156. ISSN 0031-8655, 1751-1097
Full text not available from this repository. (Request a copy)Abstract
UVC222 nm has germicidal effects with potential clinical applications. However, UVC irradiation is capable of inducing DNA damage like cyclobutylpyrimidine dimers (CPD). Although new devices have emission peaks in the short-wavelength region of UVC (similar to 222 nm), the remaining "collateral" radiation at longer wavelengths could be harmful to human health. We investigated the DNA damage caused by far-UVC 222 nm Kra exciplex radiation on human skin reconstructs after additional filtering using silica filters. The skin reconstructs were irradiated with 100 mJ cm(-2), 500 mJ cm(-2), and 3 x 500 mJ cm(-2) unfiltered and filtered (230-270 nm suppressed) far-UVC or UVB (308 nm) radiation. UVB and non-filtered UVC irradiation induced a significant amount of CPDs, compared with the background. Filtered far-UVC lowered the CPD amount compared with unfiltered UVC and UVB treatments. Repetitive UVC irradiation did not result in the accumulation of CPDs compared with UVB treatment. Reduction in excess of 99.9% of E. coli, S. aureus and C. albicans was detected after applying far-UVC radiation. This identifies a therapeutic window in which microorganisms are killed but tissue is still alive and not damaged, which could give rise to new clinical applications.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | UV-RADIATION; MECHANISMS; INFECTION; CANCER; IMPACT; LIGHT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Dermatologie und Venerologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 31 Oct 2023 06:56 |
| Last Modified: | 31 Oct 2023 06:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56542 |
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