Obermaier, Lisa and Lehle, Karla and Schmid, Stefanie and Schmid, Christof and Schratzenstaller, Thomas (2023) Introduction of a new ex vivo porcine coronary artery model: Evaluation of the direct vascular injury after stent implantation with and without dogbone effect. EUROPEAN SURGICAL RESEARCH, 63 (4). pp. 285-293. ISSN 0014-312X, 1421-9921
Full text not available from this repository. (Request a copy)Abstract
Introduction: Neointimal hyperplasia after percutaneous coronary intervention remains a major determinant of in-stent restenosis (ISR). The extent of mechanical vessel injury correlates with ISR. A new ex vivo porcine stent model was introduced and evaluated comparing different stent designs. Methods: Coronary arteries were prepared from pig hearts from the slaughterhouse and used for ex vivo implantations of coronary stents. One basic stent design in two configurations (dogbone, DB; non-dogbone, NDB) was used. Vascular injury was determined according to a modified injury score (IS). Results: Standardized experimental conditions ensured comparable vessel dimensions and overstretch data. DB stents caused more severe IS compared to NDB stents. The mean IS and the IS at the distal end of all stents were significantly reduced for NDB stents (ISMean, DB, 1.16 +/- 0.12; NDB, 1.02 +/- 0.12; p=0.018; ISDist, DB, 1.39 +/- 0.28; NDB, 1.13 +/- 0.24; p=0.03). Discussion/Conclusion: The introduced ex-vivo model allowed the evaluation of different stent designs exclude unfavorable stent designs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RESTENOSIS; OPTIMIZATION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Mar 2024 07:59 |
| Last Modified: | 05 Mar 2024 07:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56561 |
Actions (login required)
 |
View Item |
