Fante, Matthias A. and Felsenstein, Mona and Mayer, Stephanie and Gerken, Michael and Klinkhammer-Schalke, Monika and Herr, Wolfgang and Vogelhuber, Martin and Reichle, Albrecht and Heudobler, Daniel (2022) All-Oral Low-Dose Chemotherapy TEPIP is Effective and Well-Tolerated in Relapsed/Refractory Patients With Aggressive B-Cell Lymphoma. FRONTIERS IN ONCOLOGY, 12: 852987. ISSN 2234-943X,
Full text not available from this repository. (Request a copy)Abstract
PurposeTreatment options in patients (pts.) with advanced relapsed and refractory aggressive B-cell lymphoma are limited. Palliative all-oral chemotherapy regimens reduce in-patient visits and contribute to quality of life. The all-oral low-dose chemotherapy regimen TEPIP comprises the conventional chemotherapy agents trofosfamide, etoposide, procarbazine, idarubicin and prednisolone. MethodsSafety and efficacy of TEPIP was evaluated in an observational retrospective, single-center study at the University Medical Center Regensburg between 2010 and 2020. Treatment with TEPIP was applied for 7 or 10 days during a 28-days period. In a subgroup of fit and therapy-motivated pts. rituximab was added. End points were overall survival (OS) and progression free survival (PFS). Adverse events >= CTCAE grade III were reported. Results35 highly pre-treated pts. with aggressive B-cell lymphoma were enrolled. Median age at TEPIP start was 67 years and 85% of pts. received TEPIP as >= third treatment line. Overall response rate (ORR) was 23% (CR 17%). Pts. benefited from additional rituximab administration (ORR 67%) and a lower number of pre-treatments (ORR 41%). The OS was 3.3 months (m) with a 1y-OS of 25.7% and the PFS amounted to 1.3 m with a 1y-PFS of 8.8%. OS and PFS were significantly prolonged in pts. that responded to treatment or additionally received rituximab. Adverse events were mainly hematological and occurred in 49% of pts. ConclusionTEPIP was well-tolerated and induced respectable response in a difficult-to-treat patient cohort. In particular, the all-oral administration enables out-patient use with palliative intent.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NON-HODGKINS-LYMPHOMA; RITUXIMAB PLUS GEMCITABINE; ELDERLY-PATIENTS; METRONOMIC CHEMOTHERAPY; SALVAGE CHEMOTHERAPY; CHOP CHEMOTHERAPY; SINGLE-ARM; TRANSPLANTATION; REGIMEN; LENALIDOMIDE; relapsed; refractory DLBCL; metronomic chemotherapy; all-oral treatment; low-dose chemotherapy; aggressive B-cell lymphoma |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Zentren des Universitätsklinikums Regensburg > Tumorzentrum e.V. |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Feb 2024 07:25 |
| Last Modified: | 13 Feb 2024 07:25 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56574 |
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