Kuenzel, Julian and Brandenstein, Moritz and Zeman, Florian and Symeou, Luisa and Da Silva, Natascha Platz Batista and Jung, Ernst Michael (2022) Multiparametric Ultrasound of Cervical Lymph Node Metastases in Head and Neck Cancer for Planning Non-Surgical Therapy. DIAGNOSTICS, 12 (8): 1842. ISSN , 2075-4418
Full text not available from this repository. (Request a copy)Abstract
Background: We aimed to evaluate multiparametric ultrasound, to achieve a better understanding of the baseline characteristics of suspected cervical lymph node metastases in head and neck cancer before induction chemotherapy or chemoradiation. Methods: From February 2020 to April 2021, our complete ultrasound examination protocol was carried out on clinically evident malignant lymph nodes of histologically proven HNSCC in the pre-therapeutic setting. Results: A total of 13 patients were eligible for analysis. Using elastography, irregular clear hardening in areas in the center of the lymph node could be detected in all cases. Elastographic Q-analysis showed a significantly softer cortex compared to the center and surrounding tissue. The time-intensity curve analysis showed high values for the area under the curve and a short time-to-peak (fast wash-in) in all cases compared to the surrounding tissue. A parametric evaluation of contrast enhanced the ultrasound in the early arterial phase and showed an irregular enhancement from the margin in almost all investigated lymph nodes. These results show that the implementation of comprehensive, multiparametric ultrasound is suitable for classifying suspected lymph node metastasis more precisely than conventional ultrasound alone in the pre-therapeutic setting of HNSCC. Thus, these parameters may be used for improvements in the re-staging after chemoradiation or neoadjuvant therapy monitoring, respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CONTRAST-ENHANCED ULTRASOUND; CLINICAL-PRACTICE RECOMMENDATIONS; TISSUE IMAGING QUANTIFICATION; SHEAR-WAVE ELASTOGRAPHY; DIFFERENTIAL-DIAGNOSIS; EFSUMB GUIDELINES; CEUS; BENIGN; DOPPLER; LIVER; CEUS; shear wave elastography; perfusion; neck metastases; superficial lymph nodes |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 13 Feb 2024 07:53 |
| Last Modified: | 13 Feb 2024 07:53 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56583 |
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