Garcke, Harald and Kovacs, Balazs and Trautwein, Dennis (2022) Viscoelastic Cahn-Hilliard models for tumor growth. MATHEMATICAL MODELS & METHODS IN APPLIED SCIENCES, 32 (13). pp. 2673-2758. ISSN 0218-2025, 1793-6314
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We introduce a new phase field model for tumor growth where viscoelastic effects are taken into account. The model is derived from basic thermodynamical principles and consists of a convected Cahn-Hilliard equation with source terms for the tumor cells and a convected reaction-diffusion equation with boundary supply for the nutrient. Chemotactic terms, which are essential for the invasive behavior of tumors, are taken into account. The model is completed by a viscoelastic system consisting of the Navier-Stokes equation for the hydrodynamic quantities, and a general constitutive equation with stress relaxation for the left Cauchy-Green tensor associated with the elastic part of the total mechanical response of the viscoelastic material. For a specific choice of the elastic energy density and with an additional dissipative term accounting for stress diffusion, we prove existence of global-in-time weak solutions of the viscoelastic model for tumor growth in two space dimensions d = 2 by the passage to the limit in a fully-discrete finite element scheme where a CFL condition, i.e. delta t <= Ch(2), is required. Moreover, in arbitrary dimensions d & ISIN;{2, 3}, we show stability and existence of solutions for the fully-discrete finite element scheme, where positive definiteness of the discrete Cauchy-Green tensor is proved with a regularization technique that was first introduced by Barrett and Boyaval [Existence and approximation of a (regularized) Oldroyd-B model, Math. Models Methods Appl. Sci. 21 (2011) 1783-1837]. After that, we improve the regularity results in arbitrary dimensions d is an element of {2, 3} and in two dimensions d = 2, where a CFL condition is required. Then, in two dimensions d = 2, we pass to the limit in the discretization parameters and show that subsequences of discrete solutions converge to a global-in-time weak solution. Finally, we present numerical results in two dimensions d = 2.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FINITE-ELEMENT APPROXIMATION; GLOBAL WEAK SOLUTIONS; PHASE-FIELD MODEL; BRINKMAN MODEL; CHEMOTAXIS; EXISTENCE; SYSTEM; ENERGY; FLUIDS; Mathematical modeling; viscoelasticity; tumor growth; finite element method |
| Subjects: | 500 Science > 510 Mathematics |
| Divisions: | Mathematics > Prof. Dr. Harald Garcke |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Feb 2024 07:29 |
| Last Modified: | 07 Feb 2024 07:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56609 |
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