Buchner, Stefan and Wester, Michael and Hobelsberger, Sarah and Fisser, Christoph and Debl, Kurt and Hetzenecker, Andrea and Hamer, Okka W. and Zeman, Florian and Maier, Lars S. and Arzt, Michael (2022) Obstructive sleep apnoea is associated with the development of diastolic dysfunction after myocardial infarction with preserved ejection fraction. SLEEP MEDICINE, 94. pp. 63-69. ISSN 1389-9457, 1878-5506
Full text not available from this repository. (Request a copy)Abstract
Background: Left ventricular diastolic dysfunction is a predictor of adverse outcome after acute myocardial infarction (AMI). We aimed to test if sleep-disordered breathing (SDB) contributes to the development of diastolic dysfunction in patients with preserved left ventricular ejection fraction after AMI. Method: Patients with AMI, percutaneous coronary intervention and an ejection fraction >= 50% were included in this sub-analysis of a prospective observational study. Patients with AMI (n = 41) underwent cardiovascular magnetic resonance imaging (volume-time curve analysis) to define diastolic function by means of the normalised peak filling rate [nPFR; (end diastolic volume/second)]. In patients with AMI, the nPFR was assessed within <5 days and three months after AMI. Patients with AMI were stratified in patients with (apnoea-hypopnoea index, AHI >= 15/h) and without (AHI <15/h) SDB as assessed by polysomnography. Results: At the time of AMI, the nPFR was similar between patients with and without SDB (2.90 +/- 0.54 vs. 3.03 +/- 1.20, p = 0.662). Within three months after AMI, diastolic function was significantly lower in patients with SDB than in patients without SDB (AnPFR: -0.83 +/- 0.14 vs. 0.03 +/- 0.14; p < 0.001; ANCOVA, adjusted for baseline nPFR). In contrast to central AHI, obstructive AHI was associated with a lower nPFR three months after AMI, after accounting for established risk factors for diastolic dysfunction [multiple linear regression analysis, B (95%CI): -0.036 (-0.063 to -0.009), p = 0.011]. Conclusion: Our data indicate that obstructive sleep apnoea impairs diastolic function early after myocardial infarction. (C) 2022 The Authors. Published by Elsevier B.V.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMPACT; Myocardial infarction; Sleep-disordered breathing; Magnetic resonance imaging; Heart failure; Diastolic dysfunction |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 26 Jan 2024 06:08 |
| Last Modified: | 26 Jan 2024 06:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56623 |
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