Lange, Klaus W. and Lange, Katharina M. and Nakamura, Yukiko (2022) Green tea, epigallocatechin gallate and the prevention of Alzheimer?s disease: clinical evidence. FOOD SCIENCE AND HUMAN WELLNESS, 11 (4). pp. 765-770. ISSN 2213-4530
Full text not available from this repository. (Request a copy)Abstract
Given its increasing global prevalence, Alzheimer's disease (AD) has become a major public health challenge worldwide. The symptomatic treatments available for AD have shown no significant efficacy, and no disease-modifying interventions are capable of slowing the progression of the disorder. The potential of lifestyle-related factors, including diet, is increasingly recognized as an important consideration in the primary prevention of AD. Numerous mechanisms potentially underlying neuroprotective effects of bioactive components contained in tea, such as (-)-epigallocatechin-3-gallate, as well as their preventive efficacy against AD, have been elucidated in preclinical studies. However, in contrast to the abundance of mechanistic findings in animals, clinical results demonstrating effi cacy in humans are scarce. While epidemiological studies have provided some evidence indicating that green tea consumption is associated with a reduced risk of age-related cognitive decline and AD, a causal relationship cannot be established on the basis of these observations. The clinical evidence regarding preventive or therapeutic effects of green tea and its bioactive components is unsatisfactory. A role of green tea in the prevention of AD cannot be recommended until well-designed, randomized, placebo-controlled clinical trials using standardized formulations confi rm the purported benefi cial effects of green tea. (c) 2022 Beijing Academy of Food Sciences. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COGNITIVE IMPAIRMENT; MOLECULAR-MECHANISMS; MOUSE MODELS; DEMENTIA; RISK; POLYPHENOLS; BRAIN; CONSUMPTION; NEURODEGENERATION; ABSORPTION; Green tea; Epigallocatechin gallate; Alzheimer?s disease; Neurodegeneration; Prevention |
| Subjects: | 100 Philosophy & psychology > 150 Psychology 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Feb 2024 07:41 |
| Last Modified: | 07 Feb 2024 07:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56631 |
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