Neumann, Bernhard and Angstwurm, Klemens and Linker, Ralf A. and Knoll, Gertrud and Eidenschink, Lisa and Rubbenstroth, Dennis and Schlottau, Kore and Beer, Martin and Schreiner, Patrick and Soutschek, Erwin and Bohmer, Merle M. and Lampl, Benedikt M. J. and Pregler, Matthias and Scheiter, Alexander and Evert, Katja and Zoubaa, Saida and Riemenschneider, Markus J. and Asbach, Benedikt and Gessner, Andre and Niller, Hans Helmut and Schmidt, Barbara and Bauswein, Markus (2022) Antibodies against viral nucleo-, phospho-, and X protein contribute to serological diagnosis of fatal Borna disease virus 1 infections. CELL REPORTS MEDICINE, 3 (1): 100499. ISSN 2666-3791,
Full text not available from this repository. (Request a copy)Abstract
Borna disease virus 1 (BoDV-1) causes rare but often fatal encephalitis in humans. Late diagnosis prohibits an experimental therapeutic approach. Here, we report a recent case of fatal BoDV-1 infection diagnosed on day 12 after hospitalization by detection of BoDV-1 RNA in the cerebrospinal fluid. In a retrospective analysis, we detect BoDV-1 RNA 1 day after hospital admission when the cell count in the cerebrospinal fluid is still normal. We develop a new ELISA using recombinant BoDV-1 nucleoprotein, phosphoprotein, and accessory protein X to detect seroconversion on day 12. Antibody responses are also shown in seven previously confirmed cases. The individual BoDV-1 antibody profiles show variability, but the usage of three different BoDV-1 antigens results in a more sensitive diagnostic tool. Our findings demonstrate that early detection of BoDV-1 RNA in cerebrospinal fluid and the presence of antibodies against at least two different viral antigens contribute to BoDV-1 diagnosis. Physicians in endemic regions should consider BoDV-1 infection in cases of unclear encephalopathy and initiate appropriate diagnostics at an early stage.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Neurologie Medicine > Abteilung für Neuropathologie Medicine > Lehrstuhl für Pathologie Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Oct 2023 14:56 |
| Last Modified: | 17 Oct 2023 14:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56641 |
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