Mader, Anna-Lena and Tydykov, Leonid and Glueck, Vivian and Bertok, Manuela and Weidlich, Tanja and Gottwald, Christine and Stefl, Alexa and Vogel, Matthias and Plentz, Annelie and Koestler, Josef and Salzberger, Bernd and Wenzel, Juergen J. and Niller, Hans Helmut and Jantsch, Jonathan and Wagner, Ralf and Schmidt, Barbara and Glueck, Thomas and Gessner, Andre and Peterhoff, David (2022) Omicron's binding to sotrovimab, casirivimab, imdevimab, CR3022, and sera from previously infected or vaccinated individuals. ISCIENCE, 25 (4): 104076. ISSN , 2589-0042
Full text not available from this repository. (Request a copy)Abstract
SARS-CoV-2 Omicron is the first pandemic variant of concern exhibiting an abrupt accumulation of mutations particularly in the receptor-binding domain that is a critical target of vaccination induced and therapeutic antibodies. Omicron's mutations did only marginally affect the binding of ACE2, and the two antibodies Sotrovimab and CR3022 but strongly impaired the binding of Casirivimab and Imdevimab. Moreover, as compared with Wuhan, there is reduced serum reactivity and a pronounced loss of competitive surrogate virus neutralization (sVN) against Omicron in naive vaccinees and in COVID-19 convalescents after infection and subsequent vaccination. Finally, although the booster vaccination response conferred higher titers and better sVN, the effect was nonetheless significantly lower compared with responses against Wuhan. Overall, our data suggest that the antigenicity of Omicrons receptor binding motive has largely changed but antibodies such as Sotrovimab targeting other conserved sites maintain binding and therefore hold potential in prophylaxis and treatment of Omicron-induced COVID-19.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Abteilung für Krankenhaushygiene und Infektiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 07 Nov 2023 10:17 |
| Last Modified: | 07 Nov 2023 10:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/56668 |
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